• Product NameMS436
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1395084-25-9
• Calculated MW 383.42
• Formulation C18H17N5O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C/C(=N/NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3)/C(=CC1=O)N
  Pathways:Chromatin/Epigenetic
  Receptor:BRD4 (1); BRD4 (2)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 1 mg/mL warmed (2.6 mM); DMSO: 55 mg/mL (143.44 mM)
  Appearance:Red Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang G, et al. J Med Chem. 2013 Nov 27;56(22):9251-64.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting