• Product NameTMP269
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
• Target NameHDAC inhibitor
• CAS No. 1314890-29-3
• Calculated MW 514.52
• Formulation C25H21F3N4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC(F)(F)C1=NC(=NO1)C1=CC(=CC=C1)C(=O)NCC1(CCOCC1)C1=NC(=CS1)C1=CC=CC=C1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC4; HDAC5; HDAC7; HDAC9
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL warmed (3.88 mM); DMSO: 100 mg/mL (194.35 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lobera M, et al. Nat Chem Biol. 2013, 9(5), 319-325.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting