• Product NameAZD8055
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (?1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.
• Target NameDNA-PK inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 1009298-09-2
• Calculated MW 465.54
• Formulation C25H31N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[C@@H]5C
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; mTOR (full length); mTOR (truncated); PI3Kα; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 3 mg/mL (6.44 mM); DMSO: 50 mg/mL warmed (107.4 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chresta CM, et al. Y Res, 2010, 70(1), 288-298.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting