• Product NameGSK2126458(Omipalisib)
• Brief DescriptionInhibitors
• Purification99.75%
• Biological ActivityGSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 1086062-66-9
• Calculated MW 505.5
• Formulation C25H17F2N5O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(NS(=O)(=O)C2=C(F)C=C(F)C=C2)C=C(C=N1)C1=CC2=C(C=CN=C2C=C1)C1=CN=NC=C1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTORC1; p110α; p110β; p110γ; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (197.82 mM)
  Appearance:White Solid Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Knight SD, et al. ACS Med. Chem. Lett. 2010, 1 (1), 39C43.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting