• Product NamePR-619
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
• Target NameDUB inhibitor
• CAS No. 2645-32-1
• Calculated MW 223.33
• Formulation C7H5N5S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:NC1=NC(N)=C(SC#N)C=C1SC#N
  Pathways:Ubiquitination
  Receptor:JOSD2; SENP6 core; UCH-L3; USP4; USP8
  Boling pt:
  Melting pt:
  Solubility:DMSO: 45 mg/mL (201.54 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Altun M, et al. Chem Biol, 2011, 18(11), 1401-1412.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting