• Product NameJIB-04 (NSC 693627)(E)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityJIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively.
• Target NameHistone Demethylase inhibitor; Histone Methyltransferase inhibitor
• CAS No. 199596-05-9
• Calculated MW 308.76
• Formulation C17H13ClN4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1=CC=C(C=C1)/C(=N\NC2=NC=C(C=C2)Cl)/C3=CC=CC=N3
  Pathways:Chromatin/Epigenetic
  Receptor:JMJD2A; JMJD2B; JMJD2D; JMJD2E; JARID1A
  Boling pt:
  Melting pt:
  Solubility:DMSO: 25 mg/mL warmed (80.96 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang, L., et al. Nat Commun, 2013. 4: p. 2035.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting