• Product NameKobe0065
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityKobe0065 is a novel and effective small-molecule compound inhibiting RasCRaf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-RasGTP to c-Raf-1 RBD with a Ki value of 46 13 μM.
• Target NameRaf inhibitor
• CAS No. 436133-68-5
• Calculated MW 449.79
• Formulation C15H11ClF3N5O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(Cl)C=C(NC(=S)NNC2=C(C=C(C=C2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)C=C1
  Pathways:MAPK
  Receptor:Ras-Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shima F, et al. Enzymes. 2013;34 Pt. B:1-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting