• Product NameXAV939
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityXAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
• Target NamePPAR inhibitor
• CAS No. 284028-89-3
• Calculated MW 312.31
• Formulation C14H11F3N2OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC(F)(F)C1=CC=C(C=C1)C1=NC(=O)C2=C(CCSC2)N1
  Pathways:Metabolism
  Receptor:TNKS1; TNKS2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 12 mg/mL (38.42 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dregalla RC, et al. Aging, 2010, 2(10), 691-708.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting