• Product Name3-Methyladenine (3-MA)
• Brief DescriptionInhibitors
• Purification99.30%
• Biological Activity3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation.
• Target NamePI3K inhibitor
• CAS No. 5142-23-4
• Calculated MW 149.15
• Formulation C6H7N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1C=NC(N)=C2N=CN=C12
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kγ; Vps34
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 4 mg/mL (26.81 mM); DMSO: 3 mg/mL warmed (20.11 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Miller S, et al. Autophagy. 2010, 6(6), 805-807.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting