• Product NameP7C3
• Brief DescriptionInhibitors
• Purification97.02%
• Biological ActivityThe P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.
• Target NameOthers
• CAS No. 301353-96-8
• Calculated MW 474.19
• Formulation C21H18Br2N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:OC(CNC1=CC=CC=C1)CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2
  Pathways:Others
  Receptor:nicotinamide phosphoribosyltransferase
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yin TC, et al. Cell Rep. 2014 Sep 25;8(6): 1731-40.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting