• Product NameAR-A014418
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
• Target NameGSK-3 inhibitor
• CAS No. 487021-52-3
• Calculated MW 308.31
• Formulation C12H12N4O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=CC=C(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)C=C1
  Pathways:PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:GSK-3β; GSK-3β
  Boling pt:
  Melting pt:
  Solubility:DMSO: 62 mg/mL (201.09 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Carter YM, et al. Y Biol Ther. 2014, 15(5).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting