• Product NameLu-28-179
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySiramesine(Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antiY activity in vivo.
• Target Namelysosomal autophagy agonist; Sigma receptor agonist
• CAS No. 224177-60-0
• Calculated MW 491.04
• Formulation C30H32ClFN2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.FC1=CC=C(C=C1)N1C=C(CCCCN2CCC3(CC2)OCC2=CC=CC=C32)C2=CC=CC=C12
  Pathways:Autophagy; GPCR/G Protein
  Receptor:lysosome-destabilizing agent; σ2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cesen MH, et al. Cell Death Dis. 2013 Oct 3;4:e818.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting