• Product NameTAK632
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf in cell-free assays, respectively, showing less or no inhibition against other tested kinases.
• Target NameAurora Kinase inhibitor; FGFR inhibitor; PDGFR inhibitor; Raf inhibitor
• CAS No. 1228591-30-7
• Calculated MW 554.52
• Formulation C27H18F4N4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC1=C(NC(=O)CC2=CC(=CC=C2)C(F)(F)F)C=C(OC2=C(C#N)C3=C(C=C2)N=C(NC(=O)C2CC2)S3)C=C1
  Pathways:Cell Cycle/Checkpoint; Angiogenesis; MAPK; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
  Receptor:Aurora B; FGFR3; PDGFRβ; B-Raf; C-Raf
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (3.6 mM); DMSO: 100 mg/mL (180.33 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang Q, et al. EMBO Mol Med. 2012 Apr; 4(4): 298-312.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting