• Product NameInauhzin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityInauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
• Target NameSirtuin inhibitor
• CAS No. 309271-94-1
• Calculated MW 469.58
• Formulation C25H19N5OS2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCC(SC1=NC2=C(N=N1)C1=CC=CC=C1N2)C(=O)N1C2=CC=CC=C2SC2=CC=CC=C12
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:SIRT1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang Q, et al. EMBO Mol Med. 2012 Apr; 4(4): 298-31

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting