• Product NamePracinostat (SB939)
• Brief DescriptionInhibitors
• Purification99.25%
• Biological ActivityPracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I.
• Target NameHDAC inhibitor
• CAS No. 929016-96-6
• Calculated MW 358.48
• Formulation C20H30N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 27 mg/mL (75.31 mM); DMSO: 72 mg/mL (200.84 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Novotny-Diermayr V, et al. Mol Y Ther, 2010, 9(3), 642-652.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting