• Product NameKobe2602
• Brief DescriptionInhibitors
• Purification98.00%
• Biological Activitykobe2602 is a novel and effective small-molecule compound inhibiting RasCRaf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-RasGTP to c-Raf-1 RBD with a Ki value of 149 55 μM.
• Target NameRaf inhibitor
• CAS No. 454453-49-7
• Calculated MW 419.31
• Formulation C14H9F4N5O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:[O-][N+](=O)C1=CC(=CC(=C1NNC(=S)NC1=CC=C(F)C=C1)[N+]([O-])=O)C(F)(F)F
  Pathways:MAPK
  Receptor:Ras-Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shima F, et al. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting