• Product NameML 161
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityInhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
• Target NameProtease-activated Receptor inhibitor
• CAS No. 423735-93-7
• Calculated MW 361.23
• Formulation C17H17BrN2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCCC(=O)NC1=CC=CC(NC(=O)C2=CC=CC=C2Br)=C1
  Pathways:GPCR/G Protein
  Receptor:PAR-1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 72 mg/mL (199.31 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dockendorff C, et al. ACS Med Chem Lett, 2012, 3(3), 232-237.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting