• Product NameCAL-101 (Idelalisib, GS-1101)
• Brief DescriptionInhibitors
• Purification98.50%
• Biological ActivityCAL-101 (Idelalisib, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
• Target NamePI3K inhibitor; S6 Kinase inhibitor
• CAS No. 870281-82-6
• Calculated MW 415.42
• Formulation C22H18FN7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:p110α; p110β; p110γ; p110δ; hVps34
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 23 mg/mL (55.36 mM); DMSO: 83 mg/mL warmed (199.79 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lannutti BJ, et al. Blood, 2011, 117(2), 591-594.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting