• Product NameRKI-1447
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.
• Target NameROCK inhibitor
• CAS No. 1342278-01-6
• Calculated MW 326.37
• Formulation C16H14N4O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC1=CC=CC(CNC(=O)NC2=NC(=CS2)C2=CC=NC=C2)=C1
  Pathways:Cell Cycle/Checkpoint; Stem Cells
  Receptor:ROCK1; ROCK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 65 mg/mL (199.16 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Patel RA, et al. Y Res, 2012, 72(19), 5025-5034.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting