• Product NameLDN212854
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.
• Target NameALK inhibitor
• CAS No. 1432597-26-6
• Calculated MW 406.48
• Formulation C25H22N6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1CN(CCN1)C1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=C2C=CC=NC2=CC=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK1; ALK2; ALK3; ALK4; ALK5
  Boling pt:
  Melting pt:
  Solubility:DMSO: 81 mg/mL warmed (199.27 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mohedas AH, et al. ACS Chem Biol. 2013;8(6):1291-302.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting