• Product NameTG003
• Brief DescriptionInhibitors
• Purification99.04%
• Biological ActivityTG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC.
• Target NameBCL inhibitor
• CAS No. 300801-52-9
• Calculated MW 249.33
• Formulation C13H15NO2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCN\1C2=C(C=CC(=C2)OC)S/C1=C\C(=O)C
  Pathways:Apoptosis
  Receptor:mCLK1; mCLK2; mCLK4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6 mg/mL warmed (24.06 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Muraki M, et al. J Biol Chem. 2004, 279(23), 24246-24254.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting