• Product NameBAY 11-7082
• Brief DescriptionInhibitors
• Purification99.83%
• Biological ActivityBAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
• Target NameE2 conjugating inhibitor; IκB/IKK inhibitor
• CAS No. 19542-67-7
• Calculated MW 207.25
• Formulation C10H9NO2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N
  Pathways:NF-κb
  Receptor:E2-conjugating enzymes; IκBα?phosphorylation
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 10 mg/mL (48.25 mM); DMSO: 41 mg/mL (197.82 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Melisi D, et al. Expert Opin Ther Targets, 2007, 11(2), 133-144.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting