• Product NameSGI-1027
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.
• Target NameDNA Methyltransferase inhibitor
• CAS No. 1020149-73-8
• Calculated MW 461.52
• Formulation C27H23N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=CC(NC2=CC=C(NC(=O)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3)C=C2)=NC(N)=N1
  Pathways:Chromatin/Epigenetic
  Receptor:DNMT1; DNMT3A; DNMT3B
  Boling pt:
  Melting pt:
  Solubility:DMSO: 92 mg/mL (199.34 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Datta J, et al. Y Res. 2009, 69(10), 4277-4285.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting