• Product NameEPZ005687
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityEPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM in a cell-free assay, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1396772-26-1
• Calculated MW 539.67
• Formulation C32H37N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=CC(C)=C(CNC(=O)C2=C3C=NN(C4CCCC4)C3=CC(=C2)C2=CC=C(CN3CCOCC3)C=C2)C(=O)N1
  Pathways:Chromatin/Epigenetic
  Receptor:EZH2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 2 mg/mL (3.7 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Knutson SK, et al. Nat Chem Biol, 2012, 8(11), 890-896.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting