• Product NameGSK-525762A(I-BET-762)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGSK 525762A (I-BET 762) is an inhibitor for BET proteins with IC50 of ~35 nM.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1260907-17-2
• Calculated MW 423.9
• Formulation C22H22ClN5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CCNC(=O)C[C@H]1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C
  Pathways:Chromatin/Epigenetic
  Receptor:BET proteins
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 42 mg/mL warmed (99.07 mM); DMSO: 84 mg/mL (198.15 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nicodeme E, et al. Nature, 2010, 468(7327), 1119-1123.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting