• Product NameAfuresertib
• Brief DescriptionInhibitors
• Purification97.51%
• Biological ActivityAfuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).
• Target NameAkt inhibitor
• CAS No. 1047644-62-1
• Calculated MW 427.32
• Formulation C18H17Cl2FN4OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)N[C@@H](CC3=CC(=CC=C3)F)CN)Cl
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:Akt1; Akt2; Akt3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 85 mg/mL (198.91 mM); DMSO: 85 mg/mL (198.91 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Spencer A, et al. Blood. 2014 Jul 29. pii: blood-2014-03-559963.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting