• Product NameDinaciclib (SCH727965)
• Brief DescriptionInhibitors
• Purification98.21%
• Biological ActivityDinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.
• Target NameCDK inhibitor
• CAS No. 779353-01-4
• Calculated MW 396.49
• Formulation C21H28N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1; CDK2; CDK5; CDK9
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 8 mg/mL warmed (20.17 mM); DMSO: 26 mg/mL warmed (65.57 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wei Fu, et al. Molecular Y Therapeutics (2011), 10(6), 1018-1027.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting