• Product NameMK3697
• Brief DescriptionInhibitors
• Purification98.15%
• Biological ActivityMK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.
• Target NameOX Receptor antagonist
• CAS No. 1224846-01-8
• Calculated MW 447.51
• Formulation C23H21N5O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)N=C(CNC(=O)C2=CC(=NC=C2C2=NC=CS2)C2=CC(C)=CN=C2)C=C1
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:OX2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 22 mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Anthony J. Roecker, et al. Bioorganic & Medicinal Chemistry Letters Available online 26 August 2014.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting