• Product NameK 02288
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityK02288 is a novel small molecule inhibitor of ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; specific for ALK1,2,3,6 over ALK4,5; inhibitor of BMP signaling.
• Target NameALK inhibitor
• CAS No. 1431985-92-0
• Calculated MW 352.38
• Formulation C20H20N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=CC(=CC(OC)=C1OC)C1=C(N)N=CC(=C1)C1=CC(O)=CC=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK1; ALK2; ALK3; ALK4; ALK6
  Boling pt:
  Melting pt:
  Solubility:DMSO: 70 mg/mL (198.64 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sanvitale CE, et al. PLoS One. 2013, 8(4), e62721.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting