• Product NameAM251
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors; also potent GPR55 agonist (EC50 = 39 nM).
• Target NameCannabinoid Receptor antagonist
• CAS No. 183232-66-8
• Calculated MW 555.24
• Formulation C22H21Cl2IN4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(N(N=C1C(=O)NN1CCCCC1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(I)C=C1
  Pathways:GPCR/G Protein
  Receptor:CB1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 40 mg/mL (72.04 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Thewke D, et al. Biochem Biophys Res Commun, 2009, 381(2), 181-186.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting