• Product NameApitolisib (GDC-0980, RG7422)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityApitolisib (GDC-0980, RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Phase 2.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 1032754-93-0
• Calculated MW 498.6
• Formulation C23H30N8O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; p110α; p110β; p110γ; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 20 mg/mL (40.11 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sutherlin DP, et al. J Med Chem, 2011, 54(21), 7579-7587.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting