• Product Name6-BIO
• Brief DescriptionInhibitors
• Purification99.25%
• Biological ActivityBIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.
• Target NameCDK inhibitor; GSK-3 inhibitor; Tyrosine Kinases inhibitor
• CAS No. 667463-62-9
• Calculated MW 356.17
• Formulation C16H10BrN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:ONC1=C2C=CC=CC2=NC1=C1C(=O)NC2=C1C=CC(Br)=C2
  Pathways:PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; Proteases/Proteasome; Stem Cells
  Receptor:CDK1/CyclinB; CDK2/CyclinA; CDK5/p35; GSK-3; Tyk2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 21 mg/mL (58.96 mM); DMSO: 71 mg/mL (199.34 mM)
  Appearance:Deep Red Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tseng AS, et al. Chem Biol, 2006, 13(9), 957-963.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting