• Product NameTAE226 (NVP-TAE226)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
• Target Namec-Met/HGFR inhibitor; FAK inhibitor; IGF-1R inhibitor; PYK2 inhibitor
• CAS No. 761437-28-9
• Calculated MW 468.94
• Formulation C23H25ClN6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CNC(=O)C1=CC=CC=C1NC1=NC(NC2=C(OC)C=C(C=C2)N2CCOCC2)=NC=C1Cl
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:c-Met; FAK; IGF-1R; Insulin Receptor; PYK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 94 mg/mL (200.45 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu TJ, et al. Mol Y Ther, 2007, 6(4), 1357-1367.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting