• Product NameTenovin-1
• Brief DescriptionInhibitors
• Purification99.44%
• Biological ActivityTenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
• Target NameMdm2 inhibitor; p53 inhibitor
• CAS No. 380315-80-0
• Calculated MW 369.48
• Formulation C20H23N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1
  Pathways:Apoptosis
  Receptor:Mdm2; p53
  Boling pt:
  Melting pt:
  Solubility:DMSO: 74 mg/mL (200.28 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lain S, et al. Y Cell, 2008, 13(5), 454-463.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting