• Product NameAZD-5363
• Brief DescriptionInhibitors
• Purification99.60%
• Biological ActivityAZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM).
• Target NameAkt inhibitor; ROCK inhibitor
• CAS No. 1143532-39-1
• Calculated MW 428.92
• Formulation C21H25ClN6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1CN(CCC1(C(=O)N[C@@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4
  Pathways:Cytoskeletal Signaling; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:Akt1; Akt2; Akt3; ROCK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 86 mg/mL (200.5 mM)
  Appearance:Faint Pink Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Addie M, et al. J Med Chem, 2013, 26.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting