• Product NameBYL-719(Alpelisib)
• Brief DescriptionInhibitors
• Purification99.62%
• Biological ActivityAlpelisib (BYL-719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
• Target NamePI3K inhibitor
• CAS No. 1217486-61-7
• Calculated MW 441.47
• Formulation C19H22F3N5O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (4.53 mM); DMSO: 88 mg/mL (199.33 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dejan Juric, et al. 2012, AACR 103rd Annual Meeting. Abst CT-01.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting