• Product NameLDN-57444
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.
• Target NameDUB inhibitor
• CAS No. 668467-91-2
• Calculated MW 397.64
• Formulation C17H11Cl3N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
  Pathways:Ubiquitination
  Receptor:UCH-L1; UCH-L1; UCH-L3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 11 mg/mL (27.66 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cartier AE, et al. PLoS One, 2012, 7(4), e34713.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting