• Product NamePLX647
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively.
• Target Namec-Fms inhibitor; c-Kit inhibitor
• CAS No. 873786-09-5
• Calculated MW 382.38
• Formulation C21H17F3N4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:FC(F)(F)C1=CC=C(CNC2=NC=C(CC3=CNC4=C3C=CC=N4)C=C2)C=C1
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:c-Fms; c-Kit
  Boling pt:
  Melting pt:
  Solubility:DMSO: 20 mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang C, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting