• Product NameLDE225 (NVP-LDE225,Erismodegib)
• Brief DescriptionInhibitors
• Purification99.97%
• Biological ActivityLDE225 (NVP-LDE225; Erismodegib) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
• Target NameHedgehog/Smoothened antagonist
• CAS No. 956697-53-3
• Calculated MW 485.5
• Formulation C26H26F3N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Smoothened; Smoothened
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 97 mg/mL (199.79 mM); DMSO: 97 mg/mL (199.79 mM)
  Appearance:Faint Pink Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fendrich V, et al. Ann Surg, 2011, 254(5), 818-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting