• Product NameFilgotinib (GLPG0634)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGLPG0634(filgotinib) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
• Target NameJAK inhibitor; Tyrosine Kinases inhibitor
• CAS No. 1206161-97-8
• Calculated MW 425.5
• Formulation C21H23N5O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:O=C(NC1=NN2C(C=CC=C2C2=CC=C(CN3CCS(=O)(=O)CC3)C=C2)=N1)C1CC1
  Pathways:Angiogenesis; Proteases/Proteasome; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK1; JAK2; JAK3; Tyk2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 85 mg/mL (199.76 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Van Rompaey L, et al. J Immunol. 2013, 191(7), 3568-3577.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting