• Product NameLDN-193189
• Brief DescriptionInhibitors
• Purification99.86%
• Biological ActivityLDN193189(DM 3189) is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
• Target NameALK inhibitor
• CAS No. 1062368-24-4
• Calculated MW 406.48
• Formulation C25H22N6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1CN(CCN1)C1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC=CC=C12
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK2; ALK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 0.01 mg/mL (0.02 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lee YC, et al. Y Res, 2011, 71(15), 5194-5203.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting