• Product NameAlectinib
• Brief DescriptionInhibitors
• Purification99.27%
• Biological ActivityCH5424802(AF 802; Alectinib) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation.
• Target NameALK inhibitor; Tyrosine Kinases inhibitor; VEGFR inhibitor
• CAS No. 1256580-46-7
• Calculated MW 482.62
• Formulation C30H34N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCC1=C(C=C2C(=C1)C(=O)C1=C(NC3=C1C=CC(=C3)C#N)C2(C)C)N1CCC(CC1)N1CCOCC1
  Pathways:Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors
  Receptor:ALK; ALK (F1174L); ALK (R1275Q); INSR; VEGFR2?(KDR)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 0.5 mg/mL warmed (1.03 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sakamoto H, et al. Y Cell. 2011, 19(5), 679-690.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting