• Product NameSpautin-1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySpautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.
• Target NameDUB inhibitor
• CAS No. 1262888-28-7
• Calculated MW 271.26
• Formulation C15H11F2N3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC1=CC=C(CNC2=NC=NC3=C2C=C(F)C=C3)C=C1
  Pathways:Ubiquitination
  Receptor:USP10; USP13
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shao S, et al. Int J Oncol. 2014 May;44(5):1661-1668.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting