• Product NameDMH1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2.
• Target NameALK inhibitor
• CAS No. 1206711-16-1
• Calculated MW 380.44
• Formulation C24H20N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(C)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC=CC=C12
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 22 mg/mL warmed (57.82 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting