• Product NameML347
• Brief DescriptionInhibitors
• Purification99.71%
• Biological ActivityML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.
• Target NameALK inhibitor
• CAS No. 1062368-49-3
• Calculated MW 352.39
• Formulation C22H16N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=C2C=CC=NC2=CC=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK1; ALK2; ALK3; ALK6
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mg/mL (28.37 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting