• Product NameLDN-214117
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).
• Target NameALK inhibitor
• CAS No. 1627503-67-6
• Calculated MW 419.52
• Formulation C25H29N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:COC1=CC(=CC(OC)=C1OC)C1=C(C)N=CC(=C1)C1=CC=C(C=C1)N1CCNCC1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 83 mg/mL (197.84 mM); DMSO: 83 mg/mL (197.84 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mohedas AH, et al. J Med Chem. 2014 Oct 9; 57(19): 7900-15.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting