• Product NameGNE7915
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor, with IC50 and Ki of 9 nM and 1 nM, respectively.
• Target NameLRRK2 inhibitor
• CAS No. 1351761-44-8
• Calculated MW 443.4
• Formulation C19H21F4N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CCNC1=NC(NC2=C(OC)C=C(C(=O)N3CCOCC3)C(F)=C2)=NC=C1C(F)(F)F
  Pathways:Autophagy
  Receptor:LRRK2; LRRK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 22 mg/mL warmed (49.61 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Estrada AA, et al. J Med Chem. 2012, 55(22), 9416-9433.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting