• Product NameAZD4547
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.
• Target NameFGFR inhibitor; VEGFR inhibitor
• CAS No. 1035270-39-3
• Calculated MW 463.57
• Formulation C26H33N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; FGFR2; FGFR3; FGFR4; VEGFR2?(KDR)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 92 mg/mL (198.45 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gavine PR, et al. Y Res, 2012, 72(8), 2045-2056.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting