• Product NameCZC24832
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCZC24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay); exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins.
• Target NamePI3K inhibitor
• CAS No. 1159824-67-5
• Calculated MW 364.4
• Formulation C15H17FN6O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C1=CN2N=C(N)N=C2C(F)=C1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 5 mg/mL warmed (13.72 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bergamini G, et al. Nat Chem Biol, 2012, 8(6), 576-582.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting