• Product NamePND-1186
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPND-1186 (VS-4718) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. Phase 1.
• Target NameFAK inhibitor
• CAS No. 1061353-68-1
• Calculated MW 501.5
• Formulation C25H26F3N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CNC(=O)C1=CC=CC=C1NC1=CC(NC2=C(OC)C=C(C=C2)N2CCOCC2)=NC=C1C(F)(F)F
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:FAK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 24 mg/mL (47.85 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tanjoni I, et al. Y Biol Ther. 2010, 9(10), 764-777.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting